My unending research has taught what
follows to me and this truly makes me wonder what reason might exist for none
of my MD to never have even mentioned to at least (key medical word)
TRY to be treated with ANY of the plenty TNF-alpha meds (Humira, Simponi,
Cimzia and the forbidden Enbrel)
Tumor necrosis factor alpha
(TNF-α) was discovered more than a century ago, and its known roles have
extended from within the immune system to include a neuro-inflammatory domain
in the nervous system. Neuropathic pain is a recognized type of pathological
pain where nociceptive responses persist beyond the resolution of damage to the
nerve or its surrounding tissue. Very often, neuropathic pain is
disproportionately enhanced in intensity (hyperalgesia) or altered in modality
(hyperpathia or allodynia) in relation to the stimuli. At time of this writing,
there is as yet no common consensus about the etiology of neuropathic pain -
possible mechanisms can be categorized into peripheral sensitization and
central sensitization of the nervous system in response to the nociceptive
stimuli. Animal models of neuropathic pain based on various types of nerve
injuries (peripheral versus spinal nerve, ligation versus chronic constrictive
injury) have persistently implicated a pivotal role for TNF-α at both
peripheral and central levels of sensitization. Despite a lack of success in
clinical trials of anti-TNF-α therapy in alleviating the sciatic type of
neuropathic pain, the intricate link of TNF-α with other neuro-inflammatory
signaling systems (e.g., chemokines and p38 MAPK) has indeed inspired a systems
approach perspective for future drug development in treating neuropathic pain. Who's going to be the lucky one to treat me and be forever in heaven??- http://www.jneuroinflammation.com/content/7/1/27
- http://www.ncbi.nlm.nih.gov/pubmed/20398373
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861665/
- http://www.jneurosci.org/content/23/7/2517.full.pdf
- http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0092073
- http://www.hindawi.com/journals/mi/2014/861231/
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